Dr. Frasier Crane, a successful Boston therapist, moves to Seattle following his divorce to get a new start on life; he has a radio talk show, where he relays his wit and wisdom to aide callers, while dealing with a changed home life living with his salt-of-the-earth father Martin Crane (John Mahoney) and the senior Crane's physical therapist Daphne Moon (Jane Leeves). Frasier also reconnects with his sometimes uptight brother Niles Crane (David Hyde Pierce) and finds new friends among his colleagues, especially his brash show producer Roz Doyle (Peri Gilpin)